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New Crystallization Of Apixaban
May 16, 2018

New progress in the study of crystallization of Apixaban


During the study of the quality of the Apixaban, the researchers found a γ-crystalline.


Using X-ray powder diffraction data of a sample, and the scanning thermal analysis of the differential, the data show that in the 110+2,162+2, there is a gentle absorption peak, in 162-180 has exothermic peaks, the peak is located in 171+1, within 236-240 range has sharp absorption peaks. The peak is located in 238+1.


This pattern is quite different from the known data.


The polycrystalline of the Apixaban was recognized in the industry, but lacks the precise data to support it.


Next, we prepare the crystal structure confirmation and the pharmadynamics research, welcome Drug research Institutes and the Pharmaceutical Factories to carry out cooperation, in order to identify the ineffective crystal form, effective form, perhaps harmful crystal form as early as possible. 


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